Dr. Jacqueline Novak

Publications:

1.      Folzenlogen, S.L., Novak, J. and Banks, R.O. Mannitol and saline induced changes in cardiorenal actions of endothelin. Proc. Soc. Exptl. Biol. Med. 200:  378-382, 1992.

2.      Novak, J. and Banks, R.O.  Lead and nickel alter the cardiorenal actions of endothelin in the rat. Proc. Soc. Exptl. Biol. Med., 208: 191-198, 1995.

3.      Granger, J., J. Novak, C. Schnackenberg, S. Williams,  G. Reinhart.   Role of renal nerves in mediating the long-term hypertensive and renal effects of nitric oxide synthesis inhibition. Hypertension 27 (2): 613-618, 1995.

4.      Granger, J.,  C. Schnackenberg, J. Novak, B. Tucker, T. Miller, S. Morgan, and S. Kassab.  Role of nitric oxide in modulating the long-term renal and hypertensive actions of norepinehrine.  Hypertension 29(2): 205-209,1997.

5.      Novak, J., J.F. Reckelhoff,  L. Bumgarner, K. Cockrell, S.E. Kassab, J.P. Granger.  Reduced sensitivity of the renal circulation to angiotensin II in pregnant rats.  Hypertension 30(2): 580-584, 1997.

6.      Kassab, S., J. Novak,  T. Miller,  K. Kirchner, J.P. Granger.  Role of endothelin in mediating the attentuated renal hemodynamics in Dahl Salt-Sensitive Hypertension.  Hypertension 30(2):682-686, 1997.

7.      Kassab, S., M.T. Miller, R. Hester, J. Novak, J.P. Granger.   Systemic hemodynamics and regional bloodflow during chronic nitric oxide synthesis inhibition in pregnant rats. Hypertension 31(1 pt2): 315-320, 1998

8.      Kassab, S., M.T. Miller, J. Novak, J. Reckelhoff, B. Clower, J.P. Granger. Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats. Hypertension 31(2):397-402, 1998.

9.      Khalil, R.A., J.K. Crews, J. Novak, S. Kassab, J.P. Granger. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats.  Hypertension 31(5):1065-1069, 1998.

10.  Alexander B.T., M.T. Miller, S. Kassab, J. Novak, J.F. Reckelhoff, W.C. Kruckeberg, J.P. Granger. Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats. Hypertension 33(1pt2): 435-9, 1999.

11.  Granger J.P., S. Kassab, J. Novak, J.F. Reckelhoff, B. Tucker, M.T. Miller.  Role of nitric oxide in modulating renal function and arterial pressure during chronic aldosterone excess.  Am. J Physiol. 276(1 Pt 2): R197-202, 1999.

12.  Crew, J.K., J. Novak, J.P. Granger, R.A. Khalil. Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am. J Physiol. 276(2 pt2): R530-8, 1999.

13.  Conrad, K.P., L.A. Danielson, J. Novak,  L.J. Kerchner, O.D. Sherwood,  R.E. Gandley, R. J. Ramirez, and P.A. Moalli.. Is relaxin is the ?elusive? renal vasodilator of pregnancy. In: Relaxin 200 ? 3^rd International Conference on Relaxin & Related Peptides. Tregear, G.W., Ivell, R., Bathgate, R.A. and Wade, J.D., 2001.

14.  Novak J,  L.A. Danielson, L.S. Kerchner, O.D. Sherwood,  R. J. Ramirez, P.A. Moalli, and K.P. Conrad.  Relaxin is the ?elusive? renal vasodilator of pregnancy.  J. Clin. Invest., 107: 1469-1475, 2001.

15.  Conrad, K.P., R.W. Powers, A.K. Davis and J. Novak. Citrulline is not the major product using the standard ?NOS activity? assay on renal cortical homogenates. Am. J. Physiol. 282:R303-R310, 2002. 

16.  Ramirez, R.J., J. Novak, R.E. Gandley, T.P. Johnston, M.K. McLaughlin, C.A. Hubel. Endothelial function and myogenic reactivity in small mesenteric arteries of hyperlipidemic pregnant rats. Am. J. Physiol.281: R1330-1337, 2001

17.  J. Novak, R. J.J. Ramirez, R. E. Gandley, O. D. Sherwood and K. P. Conrad. Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats. Am. J. Physiol., 283:R349-R355, 2002.

18.  Jeyabalan, A.*, J. Novak*, L.A. Danielson*, L.J. Kerchner, S. L. Opett, and K. P. Conrad. Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration and reduced myogenic reactivity of small arteries. Circ Res., 93:1249-1257, 2003.

*authors contributed equally to this work

19.  Novak, J. R. J. Rajakumar, T. M. Miles, and K.P. Conrad. Nitric oxide synthase isoforms in the rat kidney during pregnancy, Journal of Society for Gynecological Investigation 11(5): 280-288, 2004.

20.  Conrad, K.P., D. O. Debrah, J. Novak , L.A. Danielson, and S.G. Shroff. Relaxin modifies systemic, arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology 145:3289-3296, 2004.

21.  Conrad, K.P., J. Novak. Emerging role of relaxin in renal and cardiovascular function. Am J. Physiol (invited review) 287:R250-R261, 2004

22.  Kerchner, L.J., J. Novak, K. Hanley-Yanez, K.D. Doty, and K.P. Conrad. Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy.  Endocrinol., Accepted with minor revisions.

23.  Ramirez, R.J.J, C.A. Hubel, J. Novak, J.R. DiCianno, V.K. Kagan, and R.E. Gandley. Moderate ascorbate deficiency increases myogenic tone of arteries from pregnant but not virgin acorbate-dependent rats. Hypertension 2006; 47:1-7, 2006.

24.  Lucitti, J., R. Visconti, J. Novak, B. Keller. Increased arterial load alters aortic structural and functional properties during embryogenesis. Am. J Physiol., in press, 2006

Presentations at National and International Meetings

1.      Poster presentation at the FASEB meeting , 1991

2.      Poster presentation at Experimental Biology Meeting, 1993Poster presentation at Experimental Biology Meeting, 1994

3.      Poster presentation at  Experimental  Biology Meeting, 1996

4.      Poster presentation at American Society of Hypertension1996

5.      Poster presentation at Experimental Biology Meeting,1997

6.      Oral presentation at the 12th Scientific Meeting The Inter-American Society of Hypertension, 1997

7.      Poster presentation at Experimental Biology Meeting, 1999

8.      Poster presentation at the Society for Gynecological Investigation, 1999

9.      Oral presentation at the Third International Conference on Relaxin and Related Peptides, 2000

10.  Oral presentation at Experimental Biology Meeting, 2001

11.  Poster presentation at Experimental Biology Meeting, 2002

12.  Poster presentation at Society for Gynecological Investigation, 2003

13.  Oral presentation at Experimental Biology Meeting, 2004

14.  Poster presentation at Experimental Biology Meeting, 2004

15.  Oral presentation at the Fourth International Conference on Relaxin and Related Peptides, 2004

16.  Oral presentation at the No-Name meeting, 2004.