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Amy Heston

Associate Professor of Chemistry

B.S., Kent State University; Ph.D., University of Akron

Walsh University
A Catholic University of Distinction
2020 East Maple Street
North Canton, Ohio44720
United States

Studying the Effects of Heavy Metal Poisoning

Studying the Effects of Heavy Metal Poisoning

Walsh student Lucy Zappitelli was attracted to Dr. Amy Heston’s cancer cell research not through a love of chemistry, but through a goal to become an oncology nurse. 

Under the direction of Dr. Amy Heston, Associate Professor of Chemistry, Walsh undergraduates are researching the devastating effects of heavy metal poisoning with the hope of creating something good out of something bad. 

It was Dr. Heston’s background in chemistry and love of forensic science that led to her current research project involving heavy metal ions and their effects on cancer cell lines such as brain, skin and breast cancer.

“Most people are aware that there are some metals that are toxic such as lead and arsenic.  Sometimes they are used as a forensic poison,” said Dr. Heston.  “I began to question if a heavy metal, such as thallium, can be used as a poison and kill cells in the body could it actually be used to kill cancer cells? Can we turn it around and do something good with something considered bad?  I began to investigate heavy metals and their effects on cancer cells. Our goal is to kill the cancer cells and leave the healthy ones alone, and I am proud to say that we have accomplished that here at Walsh. My team is very excited about these results and we will expand our study to include lung cancer cell lines.”

Dr. Heston’s team, including Dr. Joe Lupica and students Christine Stenger, David Liu and Lucy Zappitelli, presented its research at the National American Chemical Society Meeting in Philadelphia last August.  The team, including Michelle Colopy, presented its results at the National American Chemical Society Meeting in Indianapolis in September 2013. Michelle’s contribution was the focus of her senior Honors thesis as well.

"As a professor and research advisor, I feel very blessed to have such a wonderful and productive research group,” said Dr. Heston.  “My students not only have shown dedication to their academics at Walsh, but also have excelled in acquiring advanced laboratory techniques through this research experience."

Dr. Heston was awarded sabbatical for fall 2013 to continue her research projects at Walsh while collaborating with one of the top ranked forensic science institutions in the country, Marshall University, in forensic toxicology. During her leave, she also dedicated time to the development of Walsh’s first forensic science laboratory course and continue service projects to inspire young students in chemistry and forensics.

“I’ll admit that Chemistry is not my first love,” said Zappitelli.  “When Dr. Heston learned about my interest and career goals to become an oncology nurse, she invited me to join her cancer cell research team.  It’s been an invaluable experience.  Rather than focusing only on patient care, I’m developing an understanding of the disease itself and how a cancer cell operates.  This kind of knowledge can only help me to better care for my future patients fighting the disease.”

Publications

A. J. Heston, D. Banerjee, P. L. Rinaldi, C. A. Tessier "NMR characterization of the higher molecular weight byproducts formed during the synthesis of [PCl2N]3", J. Inorg. & Organomet. Poylm. & Mat., 2007, 17, 477-481.

A. J. Heston, M. J. Panzner, W. J. Youngs, C. A. Tessier "Lewis acid adducts of [PCl2N]3", Inorg. Chem., 2005, 44, 6518-6520.

A. J. Heston, M. J. Panzner, W. J. Youngs, C. A. Tessier "Acid-base chemistry of [PCl2N]3" Phosphorus, Sulfur Silicon Rel. Elem. 2004, 179, 831-837.

C. A. Tessier, A. J. Heston, D. Banerjee, A. Leigh, P. L. Rinaldi, C. Wesdemiotis "Characterization of the polymeric by-products from the synthesis of chlorophosphazenes" 37th American Chemical Society Central Regional Meeting, Frankenmuth, MI, May 16-20, 2006. (oral)

M. J. Panzner, A. J. Heston, W. J. Youngs, C. A. Tessier "Reaction of N-heterocyclic carbenes and Lewis bases with phosphonitrilic chloride trimer" 230th American Chemical Society National Meeting, Washington, DC, Aug. 28-Sept. 1, 2005. (oral)

A. J. Heston, M. J. Panzner, W. J. Youngs, D. Banerjee, P. L. Rinaldi, C. A. Tessier "Dichlorophosphazenes: A deeper look into the chemistry behind the synthesis of polyphosphazenes" 5th Ohio Inorganic Weekend, The University of Akron, Akron, OH, Nov. 12-13, 2004. (poster)

A. J. Heston, M. J. Panzner, W. J. Youngs, D. Banerjee, P. L. Rinaldi, C. A. Tessier "Synthesis and characterization of hexachlorocyclotriphosphazene adducts" 228th American Chemical Society National Meeting, Philadelphia, PA, Aug. 22-26, 2004. (oral)

A. J. Heston, M. J. Panzner, W. J. Youngs, D. Banerjee, P. L. Rinaldi, C. A. Tessier "Acid-base chemistry of [PCl2N]3 as a way of addressing irreproducibility issues in the ROP of hexachlorocyclotriphosphazene" 227th American Chemical Society National Meeting, Anaheim, CA, March 28-April 1, 2004. (oral)

A. J. Heston, D. Banerjee, C. A. Tessier "NMR spectroscopy of phosphazenes and derivatives" Chemistry Advisory Board Meeting, The University of Akron, Akron, OH, Feb. 5, 2004. (poster)

A. J. Heston, W. J. Youngs, C. A. Tessier "[NPCl2]3: A precursor to phosphazene polymers whose chemistry in well-known but at the same time misunderstood" 4th Ohio Inorganic Weekend, University of Cincinnati, Cincinnati, OH, Nov. 21-22, 2003. (oral)

A. J. Heston, C. A. Tessier "Acid-base chemistry of the phosphazene trimer: [NPCl2]3" 226th American Chemical Society National Meeting, New York City, NY, Sept. 7-11, 2003. (oral)

A. J. Heston, C. A. Tessier "Reactivity of the15N labeled trimer [15NPCl2]3", 10th International Symposium on Inorganic Rings, Burlington, VT, August 18-22, 2003. (oral)

A. J. Heston, C. A. Tessier "Carboxylate derivatives of disilanes", 36th Organosilicon Symposium, Akron, OH, May 29-31, 2003. (poster)

A. J. Heston, C. A. Tessier "Reinvestigation of the ring-opening polymerization of phosphazenes", 3rd Ohio Inorganic Weekend, University of Toledo, Toledo, OH, Nov. 1-2, 2002. (oral)

A. J. Heston, C. A. Tessier "Reinvestigation of the ring-opening polymerization of [PCl2N]3 and [PCl2N]4", The Maurice Morton Institute of Polymer Science Sponsor's Day, The University of Akron, Akron, OH, Oct. 3, 2002. (poster)

A. J. Heston, C. A. Tessier "Reinvestigation of the ring-opening polymerization of [PCl2N]3 and [PCl2N]4", 224th American Chemical Society National Meeting, Boston, MA, Aug. 18-22, 2002. (poster)

A. J. Heston, C. A. Tessier "Ring-opening polymerization of [-PCl2=N]n (n = 3 or 4)", 2nd Ohio Inorganic Weekend, Ohio University, Athens, OH, Nov. 30-Dec. 1, 2001. (poster)

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