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Timothy Smith

Assistant Professor of Chemistry

Walsh University
A Catholic University of Distinction
2020 East Maple Street
North Canton, Ohio44720
United States

Dr. Timothy Smith's research interests lie in the areas of soft materials, drug delivery agents, polymers, dendrimers, bio-organic chemistry, total synthesis, self-assembling materials, light harvesting arrays, and liquid crystalline materials.

Current projects for students include:

1. Soft materials capable of harnessing NIR/IR light hold massive potential in the materials and biological science worlds. Photoactive compounds capable of undergoing reversible switching with light/heat can be used in molecular imaging, drug delivery, and molecular devices/computing. Students involved with my research team will explore highly conjugated reverse photochromic materials with the intent of extending the absorption spectrum from the NIR into the IR region. This project holds the potential to allow for drug delivery with deep tissue penetrating IR wavelengths opening the door to specialized therapeutics for non-invasive site-specific drug delivery.
2. Cyclic fluorinated polymers hold the potential to create new materials with better processability and more optimal physical properties than their straight chain counterparts. This research holds the potential to synthesize and characterize novel polymeric materials.
3. Trigonostemon howii is a Chinese medicinal plant only distributed on Hainan Island. Recently this plant exhibited significant anti-HIV-1 reverse transcriptase activities with an EC50 value of 36.78 μg/mL in vitro. A novel tetrahydrofuran derivative (trigonohowine) was discovered as being the most potent component of this plant. This research project will be in the synthesis and evaluation of the this compound and its anti-viral capabilities.

Publications

Publications/Patents

Shasti, M.; Coutino, P.; Mukherjee, S.; Varanytsia, A.; Smith, T.; Luchette, P.; Sukhomlinova, L.; Kosa, T.; Munoz, A.; Taheri, B. ”Reverse Mode Switching of Random Laser Emmision in Dye doped Liquid Crystals under Homogeneous and Inhomogeneous Electric Fields” Photon, Res. 2016, 4(1), 7-12.

White, T.J.; Zhao, A.D.; Cazzell, S.A.; Bunning, T.J.; Kosa, T.; Sukhomlinova, L.; Smith, T.; Taheri, B. “Optically reconfigurable color change in chiral nematic liquid crystals based on indolyfulgide chiral dopants” J. Mater. Chem. 2012, 22, 5751-5757.

Shreiner, C.D.; Aleman, E.A.; Rajesh, C.S.; Smith, T.; Garrison, S.A.; Modarelli, D.A. “Photoinduced Electron-Transfer within Osmium (II) and Ruthenium (II) bis-Terpyridine Donor Acceptor Dyads” Dalton Trans. 2009, 33, 6562-77.

Smith, T.; Modarelli, D.A. “The Efficient Synthesis of Oligo (phenylenevinylenes)” Tetrahedron Letters 2008, 49, 526-528.

Coutino, P.S.; Smith, T.; Miller, R.E.; Sukhomlinova, L.; Bodnar, V.; Baker, C.; Kosa, T.; Taheri, B., Wide band variable transmittance liquid crystal optical devices. U.S. patent 20160070132 A1 20160310, March 10, 2016.

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